Evaluation of efficacy and safety of gefitinib as monotherapy in Chinese patients with advanced non-small cell lung cancer and very poor performance status

<p>Abstract</p> <p>Background</p> <p>This paper reports the outcome of gefitinib for Chinese advanced NSCLC patients with poor performance status (PS) at the Peking Union Medical College Hospital.</p> <p>Methods</p> <p>From Oct 2002 to Apr. 2006, 42 advanced NSCLC patients with PS 3/4 received gefitinib 250 mg/day treatment. Median survival (MS) were calculated using the Kaplan-Meier method and a Cox regression model was used to find main factors affecting MS.</p> <p>Results</p> <p>Adverse events (AEs) were generally mild (grade 1 and 2) and reversible. The most frequent AEs were rash 72.2% (26/42) and diarrhea 44.4% (26/42). The objective tumor response rate and stable disease rate were 40.5% and 26.2% respectively, and median survival(MS) of all patients was 10.1 months (95% confidential interval CI, 3.4 ~ 16.8), and progression-free survival(PFS) was 5.7 months (95% CI, 4.5 ~ 6.9). The MS were significantly related with objective response of gefitinib. Objective responses was significantly related with rashes induced with gefitinib.</p> <p>Conclusion</p> <p>Our study suggest that treatment with gefitinib may be well tolerated and beneficial for Chinese patients with poor PS, and the safety and efficacy were similar to patients with good PS.</p

Multisymplectic Geometry and Multisymplectic Preissman Scheme for the KP Equation

The multisymplectic structure of the KP equation is obtained directly from the variational principal. Using the covariant De Donder-Weyl Hamilton function theories, we reformulate the KP equation to the multisymplectic form which proposed by Bridges. From the multisymplectic equation, we can derive a multisymplectic numerical scheme of the KP equation which can be simplified to multisymplectic forty-five points scheme.Comment: 17 papges, 8 figure

Performance of AC-LGAD strip sensor designed for the DarkSHINE experiment

AC-coupled Low Gain Avalanche Detector (AC-LGAD) is a new precise detector technology developed in recent years. Based on the standard Low Gain Avalanche Detector (LGAD) technology, AC-LGAD sensors can provide excellent timing performance and spatial resolution. This paper presents the design and performance of several prototype AC-LGAD strip sensors for the DarkSHINE tracking system, as well as the electrical characteristics and spatial resolution of the prototype sensors from two batches of wafers with different $n^+$ dose.The range of spatial resolutions of 6.5$\mathrm{\mu m}$ $\sim$ 8.2$\mathrm{\mu m}$ and 8.8$\mathrm{\mu m}$ $\sim$ 12.3$\mathrm{\mu m}$ are achieved by the AC-LGAD sensors with 100$\mu m$ pitch size.Comment: 10 pages, 12 figure

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer.

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relative diversity and uniformity of genetic drivers upon identical germline and environmental background. We find that each multicentric primary tumor harbors distinct oncogenic alterations, including novel mutations that are experimentally demonstrated to be functional and therapeutically targetable. However, functional studies show a strikingly constrained tumorigenic pathway underlying heterogeneous genetic variants. These results suggest that although the mutation-specific routes that cells take during oncogenesis are stochastic, genetic trajectories may be constrained by selection for functional convergence on key signaling pathways. Our findings highlight the robust evolutionary pressures that simultaneously shape the expansion and constraint of genomic diversity, a principle that holds important implications for understanding tumor evolution and optimizing therapeutic strategies.Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity

The performance of large-pitch AC-LGAD with different N+ dose

AC-Coupled LGAD (AC-LGAD) is a new 4D detector developed based on the Low Gain Avalanche Diode (LGAD) technology, which can accurately measure the time and spatial information of particles. Institute of High Energy Physics (IHEP) designed a large-size AC-LGAD with a pitch of 2000 {\mu}m and AC pad of 1000 {\mu}m, and explored the effect of N+ layer dose on the spatial resolution and time resolution. The spatial resolution varied from 32.7 {\mu}m to 15.1 {\mu}m depending on N+ dose. The time resolution does not change significantly at different N+ doses, which is about 15-17 ps. AC-LGAD with a low N+ dose has a large attenuation factor and better spatial resolution. Large signal attenuation factor and low noise level are beneficial to improve the spatial resolution of the AC-LGAD sensor

Characterization of the response of IHEP-IME LGAD with shallow carbon to Gamma Irradiation

Low Gain Avalanche Detectors (LGAD), as part of High-Granularity Timing Detector (HGTD), is crucial to reducing pileup in the upgrading to HL-LHC. Many studies have been done on the bulk damages of the LGAD. However, there's no study about the surface radiation hardness of the LGAD sensors with carbon implanted. The IHEP-IME LGAD version 3 with the shallow carbon and different interpad separations were irradiated up to 2 MGy by gamma irradiation. The performance of the IHEP-IME LGAD version 3 before and after irradiation had been tested, such as the leakage current, break-down voltage, capacitance, V$_{gl}$, and inter-pad resistance. The results showed that apart from minor fluctuations in some samples, no significant changes concerning inter-pad separation were observed before and after irradiation. Leakage current and break-down voltage increase after irradiation, which is considered due to surface passivation; the overall inter-pad resistance are larger than $10^9\ \Omega$before and after irradiation; capacitance is found to be less than 4.5 pF with a slight drop in V$_{gl}$ after irradiation. All parameters meet the requirements of HGTD, and the results indicated that IHEP-IME LGAD v3 has excellent anti-irradiation performance